The article introduces a WebQuest, an inquiry-based online learning activity, as a potential tool for content-based English for Specific Purposes (ESP). It provides a series of WebQuest tasks such as summary and synthesis tasks, design tasks, negotiation and interaction tasks, analytical tasks, and scientific tasks. The article has suggestions for the effective use of WebQuests for a content-based syllabus along with a discussion of the benefits of using WebQuests to develop academic skills.